Vilgelm Laboratory - Abstract 5126: The link between therapy-induced

Journal article

A. Vilgelm, C. Johnson, Nripesh Prasad, Jinming Yang, Sheau-Chiann Chen, G. Ayers, J. Sosman, J. Ecsedy, Shyr Yu, S. Levy, A. Richmond
2016

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APA Click to copy
Vilgelm, A., Johnson, C., Prasad, N., Yang, J., Chen, S.-C., Ayers, G., … Richmond, A. (2016). Abstract 5126: The link between therapy-induced senescence and anti-tumor immune microenvironment in melanoma.

Chicago/Turabian Click to copy
Vilgelm, A., C. Johnson, Nripesh Prasad, Jinming Yang, Sheau-Chiann Chen, G. Ayers, J. Sosman, et al. “Abstract 5126: The Link between Therapy-Induced Senescence and Anti-Tumor Immune Microenvironment in Melanoma” (2016).

MLA Click to copy
Vilgelm, A., et al. Abstract 5126: The Link between Therapy-Induced Senescence and Anti-Tumor Immune Microenvironment in Melanoma. 2016.

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@article{a2016a,
  title = {Abstract 5126: The link between therapy-induced senescence and anti-tumor immune microenvironment in melanoma},
  year = {2016},
  author = {Vilgelm, A. and Johnson, C. and Prasad, Nripesh and Yang, Jinming and Chen, Sheau-Chiann and Ayers, G. and Sosman, J. and Ecsedy, J. and Yu, Shyr and Levy, S. and Richmond, A.}
}

Abstract

Tumor cell senescence is often induced by cancer therapeutics. Senescent cells secrete many proteins that may affect both malignant and non-malignant components of the tumor. The goal of this study was to determine how therapy-induced senescence (TIS) affects the immune microenvironment in melanoma. We used inhibitors of cell cycle kinases AURKA and CDK4/6 (AURKAi, CDK4/6i) to induce senescence in melanoma tumors. RNA sequencing analysis of AURKAi-treated syngeneic mouse tumors demonstrated that response to AURKA inhibition was strongly associated with induction of an immune transcriptome (p = 3.5E-29). Immunofluorescent staining and flow cytometric analysis of digested tumors showed correlation between the numbers of tumor-infiltrating leukocytes (TILs) and AURKAi response (Spearman r = -0.87, p Citation Format: Anna E. Vilgelm, C Andrew Johnson, Nripesh Prasad, Jinming Yang, Sheau-Chiann Chen, Gregory D. Ayers, Jeffrey A. Sosman, Jeffrey A. Ecsedy, Shyr Yu, Shawn E. Levy, Ann Richmond. The link between therapy-induced senescence and anti-tumor immune microenvironment in melanoma. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 5126.